EGFR tyrosine kinase inhibitors versus cranial radiation therapy for EGFR mutant non-small cell lung cancer with brain metastases: a systematic review and meta-analysis.

@article{Soon2015EGFRTK,
  title={EGFR tyrosine kinase inhibitors versus cranial radiation therapy for EGFR mutant non-small cell lung cancer with brain metastases: a systematic review and meta-analysis.},
  author={Yu Yang Soon and Cheng Nang Leong and Wee Yao Koh and Ivan W. K. Tham},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2015},
  volume={114 2},
  pages={167-72}
}
BACKGROUND AND PURPOSE EGFR TKIs alone have demonstrated activity against intracranial disease in EGFR mutant non-small cell lung cancer (NSCLC). This study aimed to determine if upfront cranial radiotherapy improves intracranial disease control and survival outcomes in EGFR mutant NSCLC with brain metastases relative to TKIs alone. MATERIALS AND METHODS We searched MEDLINE and various conference proceedings from 2008 to July 2014 for eligible studies where patients received upfront cranial… CONTINUE READING
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