EGFR tyrosine kinase inhibitor HS-10182 increases radiation sensitivity in non-small cell lung cancers with EGFR T790M mutation

@inproceedings{Chen2018EGFRTK,
  title={EGFR tyrosine kinase inhibitor HS-10182 increases radiation sensitivity in non-small cell lung cancers with EGFR T790M mutation},
  author={Yang Chen and Youyou Wang and Lujun Zhao and Ping Wang and Jifeng Sun and Rudi Bao and Chenghai Li and Ningbo Liu},
  booktitle={Cancer biology & medicine},
  year={2018}
}
Objective To investigate the potential of HS-10182, a second-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), as a radiosensitizer in non-small cell lung cancer (NSCLC). Methods Two cell lines of NSCLCs, A549 that possesses wild-type (WT) EGFRs and H1975 that possesses EGFR L858R/T790M double mutations, were treated with… CONTINUE READING