EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors.

@article{Jiang2009EGFRSR,
  title={EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors.},
  author={Huaqi Jiang and Bruce A Edgar},
  journal={Development},
  year={2009},
  volume={136 3},
  pages={483-93}
}
In holometabolous insects, the adult appendages and internal organs form anew from larval progenitor cells during metamorphosis. As described here, the adult Drosophila midgut, including intestinal stem cells (ISCs), develops from adult midgut progenitor cells (AMPs) that proliferate during larval development in two phases. Dividing AMPs first disperse, but later proliferate within distinct islands, forming large cell clusters that eventually fuse during metamorphosis to make the adult midgut… CONTINUE READING
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