EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization

@article{Lo2005EGFRSP,
  title={EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization},
  author={Hui-wen Lo and Sheng-Chieh Hsu and Mien-Chie Hung},
  journal={Breast Cancer Research and Treatment},
  year={2005},
  volume={95},
  pages={211-218}
}
SummaryAberrant epidermal growth factor receptor (EGFR) signaling is a major characteristic of many human malignancies including breast cancer. Since the discovery of EGF in 1960’s and its receptor in 1980’s, our understanding of the EGF/EGFR pathway has been significantly advanced and consequently, EGFR is considered as a major oncogenic factor and an attractive therapeutic target. The well-established traditional function of EGFR is known to transmit extra-cellular mitogenic signals, such as… CONTINUE READING

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