EGFR signaling is required for TGF-beta 1 mediated COX-2 induction in human bronchial epithelial cells.

@article{Liu2007EGFRSI,
  title={EGFR signaling is required for TGF-beta 1 mediated COX-2 induction in human bronchial epithelial cells.},
  author={Ming Liu and Seok Chul Yang and Sherven P Sharma and Jie Luo and Xiaoyan Cui and Katherine A. Peebles and Min Huang and Mitsuo Sato and Ruben D. Ramirez and Jerry W Shay and John D. Minna and Steven Dubinett},
  journal={American journal of respiratory cell and molecular biology},
  year={2007},
  volume={37 5},
  pages={578-88}
}
Cyclooxygenase-2 (COX-2) is a key enzyme in the production of prostaglandins and thromboxanes from free arachidonic acid. Increasing evidence suggests that COX-2 plays a role in tumorigenesis. A variety of stimuli induce COX-2 and it is overexpressed in many tumors, including non-small cell lung cancer (NSCLC). We studied the regulation of COX-2 expression in immortalized human bronchial epithelial cells (HBECs) by transforming growth factor-beta1 (TGF-beta1) and epidermal growth factor (EGF… CONTINUE READING