EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines.

@article{Weiss2008EGFRRB,
  title={EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines.},
  author={Glen J. Weiss and Lynne T. Bemis and Eiji Nakajima and Michio Sugita and Diane K. Birks and William A. Robinson and Marileila Varella-Garcia and Paul A. Bunn and J. S. Haney and Barbara A. Helfrich and Hisami Kato and Fred R Hirsch and Wilbur A. Franklin},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2008},
  volume={19 6},
  pages={1053-9}
}
BACKGROUND Allelic loss in chromosome 3p is one of the most frequent and earliest genetic events in lung carcinogenesis. We investigated if the loss of microRNA-128b, a microRNA located on chromosome 3p and a putative regulator of epidermal growth factor receptor (EGFR), correlated with response to targeted EGFR inhibition. Loss of microRNA-128b would be equivalent to losing a tumor suppressor gene because it would allow increased expression of EGFR. PATIENTS AND METHODS We initially showed… CONTINUE READING