EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus.

@article{Hanawa2006EGFRPO,
  title={EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus.},
  author={Mitsuhiko Hanawa and Shioto Suzuki and Yoh Dobashi and Tetsu Yamane and Koji Kono and Nobuyuki Enomoto and Akishi Ooi},
  journal={International journal of cancer},
  year={2006},
  volume={118 5},
  pages={1173-80}
}
Overexpression of epidermal growth factor receptor (EGFR) is observed in many cancers, sometimes accompanied by gene amplification. Recently, several clinical therapies targeting EGFR were developed, but the eligibility criteria for these therapies is not fully established. To develop such eligibility criteria for esophageal squamous cell carcinoma (ESCC), we sought to clarify: (i) the exact frequency of EGFR overexpression, (ii) the relationship between protein overexpression and gene… CONTINUE READING
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