EGFR phosphorylates FAM129B to promote Ras activation.


Ras GTPase-activating proteins (GAPs) are important regulators for Ras activation, which is instrumental in tumor development. However, the mechanism underlying this regulation remains elusive. We demonstrate here that activated EGFR phosphorylates the Y593 residue of the protein known as family with sequence similarity 129, member B (FAM129B), which is… (More)
DOI: 10.1073/pnas.1517112113


Cite this paper

@article{Ji2016EGFRPF, title={EGFR phosphorylates FAM129B to promote Ras activation.}, author={Haitao Ji and Jong-Ho Lee and Yugang Wang and Yilin Pang and Tao Zhang and Yan Xia and Lianjin Zhong and Jianxin Lyu and Zhimin Lu}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2016}, volume={113 3}, pages={644-9} }