EGFR negates the proliferative effect of oncogenic HER2 in MDA-MB-231 cells.

Abstract

Members of the EGFR family are potent mediators of normal cell growth and development. HER2 possesses an active tyrosine kinase domain, but no direct ligand has been identified. To investigate the differential effect of HER2 in breast cell lines, HER2 was overexpressed in MCF-10A, MCF7 and MDA-MB-231 cells. HER2 overexpression promoted proliferation… (More)
DOI: 10.1016/j.abb.2015.04.008

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