EGFR mutation L747P led to gefitinib resistance and accelerated liver metastases in a Chinese patient with lung adenocarcinoma.

@article{Yu2015EGFRML,
  title={EGFR mutation L747P led to gefitinib resistance and accelerated liver metastases in a Chinese patient with lung adenocarcinoma.},
  author={Guo-hua Yu and Xiaoxia Xie and Dengjun Sun and Junzu Geng and Fenghua Fu and Liangming Zhang and Hongbo Wang},
  journal={International journal of clinical and experimental pathology},
  year={2015},
  volume={8 7},
  pages={8603-6}
}
BACKGROUND Mutations in the epidermal growth factor receptor gene (EGFR) are found in around half of Asian patients with non-small cell lung cancer (NSCLC). For this reason, EGFR tyrosine kinase inhibitors (TKI) are often prescribed depending on the EGFR status. Two common EGFR mutations, a deletion in exon 19 and L858R in exon 21, demonstrate a positive… CONTINUE READING