EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4.

Abstract

Posttranslational modifications of histones play fundamental roles in many biological functions. Specifically, histone H4-K20 methylation is critical for DNA synthesis and repair. However, little is known about how these functions are regulated by the upstream stimuli. Here, we identify a tyrosine phosphorylation site at Y72 of histone H4, which facilitates… (More)
DOI: 10.1016/j.devcel.2014.06.008

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