EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation

@inproceedings{Fang2016EGFRMH,
  title={EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation},
  author={Qilu Fang and Chunpeng Zou and Peng Zhong and Feng Lin and Weixin Li and Lintao Wang and Yali Zhang and Chao Zheng and Yi Wang and Xiao-kun Li and Guang Liang},
  booktitle={Oncotarget},
  year={2016}
}
Previous studies have implicated inflammation, oxidative stress, and fibrosis as key factors in the development of obesity-induced kidney diseases. Epidermal growth factor receptor (EGFR) plays an important role in cancer development. Recently, the EGFR pathway has been increasingly implicated in chronic cardiovascular diseases via regulating inflammation and oxidative stress. However, it is unclear if EGFR is involved in obesity-related kidney injury. Using ApoE-/- and C57BL/6 mice models and… CONTINUE READING
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