EGFR-mediated stimulation of sodium/glucose cotransport promotes survival of irradiated human A549 lung adenocarcinoma cells.

@article{Huber2012EGFRmediatedSO,
  title={EGFR-mediated stimulation of sodium/glucose cotransport promotes survival of irradiated human A549 lung adenocarcinoma cells.},
  author={Stephan M Huber and Milan Mi{\vs}ovi{\vc} and Claus Mayer and H. Peter Rodemann and Klaus Dittmann},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2012},
  volume={103 3},
  pages={
          373-9
        }
}
BACKGROUND AND PURPOSE Solid tumor cells may adapt to an ischemic microenvironment by upregulation of sodium/glucose cotransport (SGLT) in the plasma membrane which supplies the tumor cell with glucose even at very low extracellular glucose concentration. Since SGLT activity has been shown to depend on the epithelial growth factor receptor (EGFR) and EGFR reportedly is activated by ionizing radiation, we tested for irradiation-induced SGLT activity. MATERIALS AND METHODS A549 lung… CONTINUE READING

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