EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma.

@article{Liu2002EGFRIA,
  title={EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma.},
  author={David Xianhong Liu and Julio Aguirre Ghiso and Yeriel D Estrada and L. L. J. Ossowski},
  journal={Cancer cell},
  year={2002},
  volume={1 5},
  pages={445-57}
}
Urokinase plasminogen activator receptor (uPAR) activates alpha5beta1 integrin and ERK signaling, inducing in vivo proliferation of HEp3 human carcinoma. Here we demonstrate that EGFR mediates the uPAR/integrin/fibronectin (FN) induced growth pathway. Its activation is ligand-independent and does not require high EGFR, but does require high uPAR expression. Only when uPAR level is constitutively elevated does EGFR become alpha5beta1-associated and activated. Domain 1 of uPAR is crucial for EGFR… CONTINUE READING
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