EGFR inhibitors sensitize non–small cell lung cancer cells to TRAIL-induced apoptosis

@inproceedings{Xu2011EGFRIS,
  title={EGFR inhibitors sensitize non–small cell lung cancer cells to TRAIL-induced apoptosis},
  author={Fei Xu and Ying Tian and Yan Huang and Ling-ling Zhang and Zheng-zheng Guo and Jia-jia Huang and Tong-yu Lin},
  booktitle={Chinese journal of cancer},
  year={2011}
}
Apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can be regulated by the epidermal growth factor (EGF) signaling pathway. In this study, recombinant adenoviral vectors that encode TRAIL gene from the hTERT/RGD promoter (AdTRAIL) was combined with drugs including gefitinib, elotinib, and cetuximab that inhibit EGFR and the EGF signaling pathway in non-small cell lung cancer (NSCLC) cell lines to investigate their antitumor activity. In vitro, compared to… CONTINUE READING

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SHOWING 1-10 OF 41 REFERENCES

cellular cytotoxicity mediated by cetuximab against lung cancer cell lines [J

S Van Schaeybroeck, J Kyula, DM Kelly
  • Clin Cancer Res,
  • 2007