EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells.

@article{Kim2011EGFRIE,
  title={EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells.},
  author={Honghyuk Kim and Sun-Hee Kim and Mi-ju Kim and Sojung Kim and Soo-jung Park and Joo-Seop Chung and Jae-Ho Bae and Chi‑Dug Kang},
  journal={Journal of immunotherapy},
  year={2011},
  volume={34 4},
  pages={
          372-81
        }
}
  • Honghyuk Kim, Sun-Hee Kim, +5 authors Chi‑Dug Kang
  • Published in Journal of immunotherapy 2011
  • Biology, Medicine
  • As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK -cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands. In this study, it was investigated whether EGFR inhibitors, including erlotinib or gefitinib, could regulate expression of… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 18 CITATIONS

    Enhanced interaction between natural killer cells and lung cancer cells: involvement in gefitinib-mediated immunoregulation

    VIEW 10 EXCERPTS
    CITES RESULTS & BACKGROUND
    HIGHLY INFLUENCED

    Immunotherapy in EGFR mutant non-small cell lung cancer: when, who and how?

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 68 REFERENCES

    Phosphorylation of the human microRNAgenerating complex mediates MAPK / Erk signal

    • KF Tang, H Ren, J Cao
    • Cell
    • 2009

    Proteasome regulation of ULBP1 transcription.

    VIEW 2 EXCERPTS

    lines

    • M Fukuoka, S Yano, G Giaccone
    • Cancer
    • 2009