EGFR in melanoma: clinical significance and potential therapeutic target.

  title={EGFR in melanoma: clinical significance and potential therapeutic target.},
  author={Barbara Boone and Koen Jacobs and Liesbeth Ferdinande and Jasmien Taildeman and Jo Lambert and Marc Peeters and Marc E. Bracke and Patrick Pauwels and Li{\`e}ve Brochez},
  journal={Journal of cutaneous pathology},
  volume={38 6},
BACKGROUND The role of epidermal growth factor receptor (EGFR) has been established in a range of neoplasms. In melanoma, data on EGFR protein expression are conflicting. Fluorescence in situ hybridization (FISH) analysis for EGFR gene expression in melanoma showed EGFR gene amplification to be linked with worse prognosis. Cetuximab has been shown to suppress the formation of metastasis in mice. METHODS EGFR protein expression and gene copy number status were evaluated by means of… CONTINUE READING


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