EGFR function and detection in cancer therapy.

  title={EGFR function and detection in cancer therapy.},
  author={John P Fruehauf},
  journal={Journal of experimental therapeutics & oncology},
  volume={5 3},
  • John P Fruehauf
  • Published 2006 in Journal of experimental therapeutics & oncology
There is strong evidence to support targeting the epidermal growth factor receptor (EGFR) for cancer therapy. Monoclonal antibodies targeting the ligand-binding region of the receptor and receptor tyrosine kinase inhibitors have shown promising results in subgroups of patients. Although the EGFR appears to have prognostic significance in many solid tumors, the lack of predictive capability of EGFR assessment using immunohistochemistry (IHC) in clinical trials of EGFR inhibitors has raised… CONTINUE READING