EGFR family: structure physiology signalling and therapeutic targets.

  title={EGFR family: structure physiology signalling and therapeutic targets.},
  author={Antony W. Burgess},
  journal={Growth factors},
  volume={26 5},
There are four members of the EGFR family: EGFR, erbB2, erbB3 and erbB4. These receptors form ligand-activated oligomers which regulate intracellular processes via an oligomeric tyrosine kinase scaffold. The receptors are activated when the extracellular domain undergoes a conformational change which facilitates either homo- or hetero-oligomerization with other family members. The absence of one EGFR family member leads to embryonic or early post-natal death due to implantation, central nervous… CONTINUE READING


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