EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies

@inproceedings{Derer2013EGFREL,
  title={EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies},
  author={Stefanie Derer and Stefan Lohse and Thomas Valerius},
  booktitle={Oncoimmunology},
  year={2013}
}
Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFR-specific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumor-cell killing. These results suggest that the predominant… CONTINUE READING