EGFR enhances early healing after cutaneous incisional wounding.

  title={EGFR enhances early healing after cutaneous incisional wounding.},
  author={Susan K. Repertinger and Erica L. Campagnaro and Jill Fuhrman and Taghrid Bahig El-Abaseri and Stuart H. Yuspa and Laura A. Hansen},
  journal={The Journal of investigative dermatology},
  volume={123 5},
The epidermal growth factor receptor (EGFR) has been implicated in the regulation of wound healing. In order to directly evaluate the role of endogenous EGFR in cutaneous incisional wound healing, we examined EGFR null- and wild-type skin after injury. By 5 d after wounding, re-epithelialization was complete in all EGFR wild-type wounds, but in only 40% of EGFR null wounds. Delayed wound closure in EGFR null skin was accompanied by an increase in edema, longer lasting and more prominent eschar… CONTINUE READING
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