EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling.

  title={EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling.},
  author={Rajeswara Rao Arasada and Joseph M. Amann and Mohammad Aminur Rahman and Stacey S. Huppert and David Paul Carbone},
  journal={Cancer research},
  volume={74 19},
Mutations in the epidermal growth factor receptor (EGFR) are the most common actionable genetic abnormalities yet discovered in lung cancer. However, targeting these mutations with kinase inhibitors is not curative in advanced disease and has yet to demonstrate an impact on potentially curable, early-stage disease, with some data suggesting adverse outcomes. Here, we report that treatment of EGFR-mutated lung cancer cell lines with erlotinib, while showing robust cell death, enriches the ALDH… CONTINUE READING
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