EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2.

@article{Klessner2009EGFRAA,
  title={EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2.},
  author={Jodi L. Klessner and Bhushan V. Desai and Evangeline V. Amargo and Spiro Getsios and Kathleen Janee Green},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 1},
  pages={
          328-37
        }
}
Regulation of classic cadherins plays a critical role in tissue remodeling during development and cancer; however, less attention has been paid to the importance of desmosomal cadherins. We previously showed that EGFR inhibition results in accumulation of the desmosomal cadherin, desmoglein 2 (Dsg2), at cell-cell interfaces accompanied by inhibition of matrix metalloprotease (MMP)-dependent shedding of the Dsg2 ectodomain and tyrosine phosphorylation of its cytoplasmic domain. Here, we show… CONTINUE READING

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