EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP.

Abstract

MT4-MMP (MMP-17) is a glycosylphosphatidyl inositol-anchored matrix metalloprotease expressed on the surface of cancer cells that promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver of cancer cell proliferation through CDK4 activation and retinoblastoma protein inactivation. We also determine a functional link… (More)
DOI: 10.1158/0008-5472.CAN-13-2994

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Cite this paper

@article{Paye2014EGFRAA, title={EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP.}, author={Alexandra Paye and Alice Truong and Cassandre Yip and Jonathan Cimino and Silvia Blacher and Carine Munaut and Didier Cataldo and Jean - Michel Foidart and Erik Maquoi and Joelle Collignon and Philippe Delvenne and G. H. M. Jerusalem and Agn{\`e}s Noel and Nor Eddine Sounni}, journal={Cancer research}, year={2014}, volume={74 23}, pages={6758-70} }