EGFR-Targeted TRAIL and a Smac Mimetic Synergize to Overcome Apoptosis Resistance in KRAS Mutant Colorectal Cancer Cells

@inproceedings{Moeller2014EGFRTargetedTA,
  title={EGFR-Targeted TRAIL and a Smac Mimetic Synergize to Overcome Apoptosis Resistance in KRAS Mutant Colorectal Cancer Cells},
  author={Yvonne Moeller and Martin Siegemund and Sven Beyes and Ricarda Herr and Daniele Lecis and Domenico Delia and Roland E Kontermann and Tilman Brummer and Klaus Pfizenmaier and Monilola A. Olayioye},
  booktitle={PloS one},
  year={2014}
}
TRAIL is a death receptor ligand that induces cell death preferentially in tumor cells. Recombinant soluble TRAIL, however, performs poorly as an anti-cancer therapeutic because oligomerization is required for potent biological activity. We previously generated a diabody format of tumor-targeted TRAIL termed Db(αEGFR-sc)TRAIL, comprising single-stranded TRAIL molecules (scTRAIL) and the variable domains of a humanized variant of the EGFR blocking antibody Cetuximab. Here we define the… CONTINUE READING
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