EGFR Signaling and Drug Discovery

@article{Lurje2009EGFRSA,
  title={EGFR Signaling and Drug Discovery},
  author={Georg Lurje and Heinz-Josef Lenz},
  journal={Oncology},
  year={2009},
  volume={77},
  pages={400 - 410}
}
Dysregulation of human epidermal growth factor receptor (ErbB/HER) pathways by over-expression or constitutive activation can promote tumor processes including angiogenesis and metastasis and is associated with poor prognosis in many human malignancies. In addition to cancer, ErbB signaling has also been implicated in cardiovascular and neurodegenerative diseases. Conversely, inhibition of ErbB pathways with targeted agents, such as monoclonal antibodies (MoAbs) or tyrosine kinase inhibitors… 

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