EGFR Overexpressed in Colonic Neoplasia Can be Detected on Wide-Field Endoscopic Imaging

  title={EGFR Overexpressed in Colonic Neoplasia Can be Detected on Wide-Field Endoscopic Imaging},
  author={Juan Zhou and Bishnu P Joshi and Xiyu Duan and Asha Pant and Zhen Qiu and Rork Kuick and Scott R. Owens and Thomas D. Wang},
  journal={Clinical and Translational Gastroenterology},
Objectives:Colorectal cancer initially lies dormant as dysplasia, a premalignant state that provides an opportunity for early cancer detection. Dysplasia can be flat in morphology, focal in size, and patchy in distribution, and thus it appears “invisible” on conventional wide-field endoscopy.Aims:We aim to develop and validate a peptide that is specific for epidermal growth factor receptor (EGFR), a cell surface target that is overexpressed in colonic adenomas and is readily accessible for… CONTINUE READING
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