EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients.

@article{Cappuzzo2007EGFRFA,
  title={EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients.},
  author={Federico Cappuzzo and Giovanna Finocchiaro and Ernesto Rossi and P A J{\"a}nne and Carlo Carnaghi and Cesare Calandri and Katia Bencardino and Claudia Ligorio and Fortunato Ciardiello and Tiziana Pressiani and Annarita Destro and M Roncalli and Lucio Crin{\`o} and Wilbur Franklin and Armando Santoro and Marileila Varella‐Garcia},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2007},
  volume={19 4},
  pages={
          717-23
        }
}
BACKGROUND Standardized conditions to distinguish subpopulations of colorectal cancer (CRC) patients more and less sensitive to cetuximab therapy remain undefined. MATERIALS AND METHODS We retrospectively analyzed epidermal growth factor receptor (EGFR) copy number by fluorescence in situ hybridization (FISH) in paraffin-embedded tumor blocks from 85 chemorefractory CRC patients treated with cetuximab. Results were analyzed according to different score systems previously reported in… CONTINUE READING

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