EGFR Activation Mediates Inhibition of Axon Regeneration by Myelin and Chondroitin Sulfate Proteoglycans

@article{Koprivica2005EGFRAM,
  title={EGFR Activation Mediates Inhibition of Axon Regeneration by Myelin and Chondroitin Sulfate Proteoglycans},
  author={Vuk Koprivica and Kin-Sang Cho and Jong Bae Park and Glenn Yiu and Jasvinder K. Atwal and Bryan B. Gore and Jieun A. Kim and Estelle Lin and Marc Tessier-Lavigne and Dong Feng Chen and Zhigang He},
  journal={Science},
  year={2005},
  volume={310},
  pages={106 - 110}
}
Inhibitory molecules associated with myelin and the glial scar limit axon regeneration in the adult central nervous system (CNS), but the underlying signaling mechanisms of regeneration inhibition are not fully understood. Here, we show that suppressing the kinase function of the epidermal growth factor receptor (EGFR) blocks the activities of both myelin inhibitors and chondroitin sulfate proteoglycans in inhibiting neurite outgrowth. In addition, regeneration inhibitors trigger the… 
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