EGFR/Met association regulates EGFR TKI resistance in breast cancer

@inproceedings{Mueller2010EGFRMetAR,
  title={EGFR/Met association regulates EGFR TKI resistance in breast cancer},
  author={Kelly L. Mueller and Zeng-quan Yang and Ramsi Haddad and Stephen P Ethier and Julie L. Boerner},
  booktitle={Journal of molecular signaling},
  year={2010}
}
Breast cancers show a lack of response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), despite 30% of tumors expressing EGFR. The mechanism of this resistance is unknown; however, we have recently shown that Met kinase activity compensates for loss of EGFR kinase activity in cell culture models. Met has been implicated in the pathogenesis of breast tumors and therefore may cooperate with EGFR for tumor growth. Here we have found that EGFR phosphorylation and cell… CONTINUE READING