EGFL6 promotes endothelial cell migration and angiogenesis through the activation of extracellular signal-regulated kinase.

@article{Chim2011EGFL6PE,
  title={EGFL6 promotes endothelial cell migration and angiogenesis through the activation of extracellular signal-regulated kinase.},
  author={Shek Man Chim and An Jun Qin and Jennifer C Tickner and Nathan Pavlos and Tamara Davey and Hao Wang and Y. -K. Guo and Ming H. Zheng and Jiake Xu},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 25},
  pages={22035-46}
}
Angiogenesis is required for bone development, growth, and repair. It is influenced by the local bone environment that involves cross-talks between endothelial cells and adjacent bone cells. However, data regarding factors that directly contribute to angiogenesis by bone cells remain poorly understood. Here, we report that EGFL6, a member of the epidermal growth factor (EGF) repeat superfamily proteins, induces angiogenesis by a paracrine mechanism in which EGFL6 is expressed in osteoblastic… CONTINUE READING