EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor.

@article{Traverse1994EGFTN,
  title={EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor.},
  author={Sarah Traverse and K Seedorf and Hugh Paterson and Christopher J. Marshall and Philip S. Cohen and Axel Ullrich},
  journal={Current biology : CB},
  year={1994},
  volume={4 8},
  pages={694-701}
}
BACKGROUND Mitogen-activated protein (MAP) kinase is the central component of a signal transduction pathway that is activated by growth factors interacting with receptors that have protein tyrosine kinase activity. The stimulation of PC12 phaeochromocytoma cells with nerve growth factor leads to the sustained activation and nuclear translocation of the p42 and p44 isoforms of MAP kinase and induces the differentiation of these chromaffin cells to a sympathetic-neuron-like phenotype. In contrast… CONTINUE READING
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