EGF stimulates rat spermatogonial DNA synthesis in seminiferous tubule segments in vitro.

@article{WahabWahlgren2003EGFSR,
  title={EGF stimulates rat spermatogonial DNA synthesis in seminiferous tubule segments in vitro.},
  author={Aida Wahab-Wahlgren and Nina Martinelle and Mikael Holst and Kirsi Jahnukainen and Martti Parvinen and Olle S{\"o}der},
  journal={Molecular and cellular endocrinology},
  year={2003},
  volume={201 1-2},
  pages={39-46}
}
Epidermal growth factor (EGF) superfamily of peptide growth factors (EGF-GFs) plays a role in male germ cell development, but the precise function is yet to be defined. The present study shows that EGF-GFs stimulate spermatogonial proliferation in vitro. The EGF-GF ligands, EGF, transforming growth factor-alpha and betacellulin all stimulated DNA synthesis in microdissected stage I segments of rat testis seminiferous tubules in vitro, as revealed by 3H-thymidine incorporation and 5-bromo-2… CONTINUE READING

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