EGF stimulates lamellipod extension in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism

@article{Segall1996EGFSL,
  title={EGF stimulates lamellipod extension in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism},
  author={Jeffrey E Segall and Sangeeta Tyerech and Lucia Boselli and Susan J Masseling and Joseph Helft and Amanda Kar-Men Chan and Joan G. Jones and John S Condeelis},
  journal={Clinical & Experimental Metastasis},
  year={1996},
  volume={14},
  pages={61-72}
}
Changes in lamellipod extension and chemotaxis in response to EGF were analysed for MTLn3 cells (a metastatic cell line derived from the 13762NF rat mammary adenocarcinoma). Addition of EGF produced a cessation of ruffling followed by extension of hyaline lamellipods containing increased amounts of F-actin at the growing edge. A non-metastatic cell line (MTC) derived from the same tumor did not show such responses. Lamellipod extension was maximal within 5 min, followed by retraction and… CONTINUE READING

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