EGF-related antisense oligonucleotides inhibit the proliferation of human ovarian carcinoma cells.

@article{Casamassimi2000EGFrelatedAO,
  title={EGF-related antisense oligonucleotides inhibit the proliferation of human ovarian carcinoma cells.},
  author={Amelia Casamassimi and Antonella De Luca and Sudhir Agrawal and K. Stromberg and David Scott Salomon and Nicola Normanno},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2000},
  volume={11 3},
  pages={
          319-25
        }
}
BACKGROUND The epidermal growth factor (EGF)-like peptides CRIPTO (CR), amphiregulin (AR) and transforming growth factor alpha (TGFalpha) are expressed in human ovarian carcinomas. MATERIALS AND METHODS The expression of AR, CR and TGFalpha in ovarian carcinoma cell lines was assessed by immunocytochemistry and reverse transcriptase polymerase chain reaction (RT-PCR). The antiproliferative effects of antisense phosphorothioate oligodeoxynucleotides (AS S-Oligos) directed against either AR, CR… CONTINUE READING
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