EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cells

@inproceedings{Wang2010EGFRS,
  title={EGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cells},
  author={Haijuan Wang and Katarina Gambosova and Zachary A Cooper and Michael P. Holloway and Andrea Kassai and Denisse Izquierdo and Kelly A Cleveland and Charlotte M. Boney and Rachel A. Altura},
  booktitle={BMC Molecular Biology},
  year={2010}
}
Postnatal expansion of the pancreatic β-cell mass is required to maintain glucose homeostasis immediately after birth. This β-cell expansion is regulated by multiple growth factors, including glucose, insulin, insulin-like growth factor (IGF-1) and epidermal growth factor (EGF). These mitogens signal through several downstream pathways (AKT, ERK, STAT3, and JNK) to regulate the survival and proliferation of β-cells. Survivin, an oncofetal protein with both pro-proliferative and anti-apoptotic… CONTINUE READING
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