EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors.

@article{Voisin2002EGFRT,
  title={EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors.},
  author={Laure Voisin and Sylvain Foisy and Edith Giasson and Chantal Lambert and Pierre Moreau and Sylvain Meloche},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={283 2},
  pages={C446-55}
}
The epidermal growth factor receptor (EGFR) was recently identified as a signal transducer of G protein-coupled receptors (GPCRs). In this study, we have examined the contribution of EGFR transactivation to the growth-promoting effect of GPCRs on vascular smooth muscle cells. Activation of the G(q)-coupled ANG II receptor or G(i)-coupled lysophosphatidic acid receptor resulted in increased tyrosine phosphorylation and activation of EGFR. Specific inhibition of EGFR kinase activity by tyrphostin… CONTINUE READING
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