EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL

@article{Stoll1998EGFRS,
  title={EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL},
  author={Stefan Stoll and Mary Benedict and Raj Mitra and Annie Hiniker and James T. Elder and Gabriel N{\'u}{\~n}ez},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={1493-1499}
}
Signaling through the epidermal growth factor receptor (EGFR) has been primarily implicated in the growth of epithelial cells including keratinocytes. However, the mechanism by which EGFR stimulation promotes keratinocyte cell growth is poorly understood. Here we report that human keratinocytes undergo apoptosis when incubated with the blocking EGFR monoclonal antibody 225 IgG, or PD153035, a highly specific EGFR tyrosine kinase inhibitor. Endogenous mRNA and protein levels of Bcl-XL, a member… CONTINUE READING
39 Citations
10 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 10 references

Proc

  • U Rodeck, M Jost, +4 authors DL. Ewert
  • Natl. Acad. Sci. USA, 94, 5067 ± 5072.
  • 1997

Apoptosis and Cell Cycle Control in Cancer

  • GI Evan, E Harrington, N McCarthy, C Gilbert, MA Benedict, G. Nunez
  • Thomas NSB (ed).: London.
  • 1996
1 Excerpt

Biochem

  • SJ Nass, M Li, LT Amundadottir, PA Furth, RB. Dickson
  • Biophys. Res. Commun., 227, 248 ± 256.
  • 1996

Int

  • M Naef, M Yokoyama, H Friess, MW Buchler, M. Korc
  • J. Cancer, 66, 315 ± 321.
  • 1996
2 Excerpts

Mol

  • TG Ram, CA Dilts, ML Dziubinski, LJ Pierce, SP. Ethier
  • Carcinog., 15, 227 ± 238.
  • 1996

Advances in Dermatology, Vol

  • J. Elder
  • 10. Dahl M (ed). Mosby-Year Book: St Louis, pp 99…
  • 1995
2 Excerpts

Br

  • WJ Rachwal, PF Bongiorno, MB Orringer, RI Whyte, SP Ethier, DG. Beer
  • J. Cancer, 72, 56 ± 64.
  • 1995
2 Excerpts

J

  • X Wu, Z Fan, H Masui, N Rosen, J. Mendelsohn
  • Clin. Invest., 95, 1897 ± 1905.
  • 1995

Epidermal Growth Factors and Cytokines

  • J. Elder
  • Luger T and Schwartz T. (eds). Marcel Dekker, Inc…
  • 1994
2 Excerpts

Immunol

  • RA Lang, Burgess AW.
  • Today, 11, 244 ± 249.
  • 1990

Similar Papers

Loading similar papers…