EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells

@article{Turnert2004EGFRS,
  title={EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells},
  author={Timothy Turnert and Philip T. Chen and Lyndon J. Goodly and Alan NWells},
  journal={Clinical & Experimental Metastasis},
  year={2004},
  volume={14},
  pages={409-418}
}
  • Timothy Turnert, Philip T. Chen, +1 author Alan NWells
  • Published 2004
  • Medicine, Biology
  • Clinical & Experimental Metastasis
  • Carcinomas of the prostate and other lineages often present an autocrine stimulatory loop acting via the EGF receptor (EGFR). We have recently shown that EGFR-mediated signals enhance DU-145 prostate carcinoma cell transmigration of an extracellular matrix in vitro, and that this increased invasiveness was independent of proteolytic degradation of the matrix (Xie et al., 1995, Clin Exp Metastasis, 13, 407). To determine whether up-regulated EGFR signaling promotes tumor progression in vivo and… CONTINUE READING

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