EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCgamma signaling pathway.

@article{Xie1998EGFRR,
  title={EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCgamma signaling pathway.},
  author={Heidi Q. H. Xie and Manuel Antonio Pallero and Kalpna Gupta and Philip Chang and Matthew F Ware and Walter Witke and D. J. Kwiatkowski and Douglas A. Lauffenburger and Joanne E Murphy-Ullrich and Alan Wells},
  journal={Journal of cell science},
  year={1998},
  volume={111 ( Pt 5)},
  pages={615-24}
}
A current model of growth factor-induced cell motility invokes integration of diverse biophysical processes required for cell motility, including dynamic formation and disruption of cell/substratum attachments along with extension of membrane protrusions. To define how these biophysical events are actuated by biochemical signaling pathways, we investigate here whether epidermal growth factor (EGF) induces disruption of focal adhesions in fibroblasts. We find that EGF treatment of NR6… CONTINUE READING

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The short - term ( 30 minutes ) disassembly of focal adhesions is reflected in decreased adhesiveness of EGF - treated cells to substratum .
We have previously demonstrated that phospholipase C(gamma ) ( PLCgamma ) activation and mobilization of gelsolin from a plasma membrane - bound state are required for EGFR - mediated cell motility .
We have previously demonstrated that phospholipase C(gamma ) ( PLCgamma ) activation and mobilization of gelsolin from a plasma membrane - bound state are required for EGFR - mediated cell motility .
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