EGF receptor modifies cellular responses to hyaluronan in glioblastoma cell lines.

@article{Tsatas2002EGFRM,
  title={EGF receptor modifies cellular responses to hyaluronan in glioblastoma cell lines.},
  author={Dina Tsatas and Varuni Kanagasundaram and Andrew L Kaye and Ulrike Novak},
  journal={Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  year={2002},
  volume={9 3},
  pages={282-8}
}
Cell contact with the extracellular matrix component, hyaluronan, plays a pivotal role in glioma cell invasion and proliferation. Although it is well established that glioma cells can bind hyaluronan to their surface via the expression of CD44, the cellular responses following ligand-receptor interaction remain poorly understood. Given that a large proportion of human high grade gliomas over express the epidermal growth factor receptor (EGFR) and ErbB2, this study aimed to investigate whether… CONTINUE READING