EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation.

@article{Joslin2007EGFreceptormediatedME,
  title={EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation.},
  author={Elizabeth J Joslin and Lee K. Opresko and Alan Wells and H. Steven Wiley and Douglas A. Lauffenburger},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 20},
  pages={3688-99}
}
EGF family ligands are synthesized as membrane-anchored precursors whose proteolytic release yields mature diffusible factors that can activate cell surface receptors in autocrine or paracrine mode. Expression of these ligands is altered in pathological states and in physiological processes, such as development and tissue regeneration. Despite the widely documented biological importance of autocrine EGF signaling, quantitative relationships between protease-mediated ligand release and… CONTINUE READING