EGF receptor family: twisting targets for improved cancer therapies.

  title={EGF receptor family: twisting targets for improved cancer therapies.},
  author={Antony W. Burgess and Yoav I. Henis and Nancy E. Hynes and Thomas M. Jovin and Alexander Levitzki and Ronit Pinkas-Kramarski and Yosef Yarden},
  journal={Growth factors},
  volume={32 2},
The epidermal growth factor receptor (EGFR) undergoes a conformational change in response to ligand binding. The ligand-induced changes in cell surface aggregation and mobility have a profound effect on the function of all the family members. Ligand also activates the EGFR intracellular kinase, stimulating proliferation and cell survival. The EGFR family are often activated, overexpressed or mutated in cancer cells and therapeutic drugs (including antibodies) can slow the progress of some… CONTINUE READING
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