EGF receptor attenuates Dpp signaling and helps to distinguish the wing and leg cell fates in Drosophila.

@article{Kubota2000EGFRA,
  title={EGF receptor attenuates Dpp signaling and helps to distinguish the wing and leg cell fates in Drosophila.},
  author={Kazumasa Kubota and Sumio Goto and Kazuhiro Eto and Shigeo Hayashi},
  journal={Development},
  year={2000},
  volume={127 17},
  pages={
          3769-76
        }
}
Wing and leg precursors of Drosophila are recruited from a common pool of ectodermal cells expressing the homeobox gene Dll. Induction by Dpp promotes this cell fate decision toward the wing and proximal leg. We report here that the receptor tyrosine kinase EGFR antagonizes the wing-promoting function of Dpp and allows recruitment of leg precursor cells from uncommitted ectodermal cells. By monitoring the spatial distribution of cells responding to Dpp and EGFR, we show that nuclear… CONTINUE READING
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