EGF inhibits secretagogue-induced cAMP production and amylase secretion by Gi proteins in pancreatic acini.

@article{StryjekKaminska1995EGFIS,
  title={EGF inhibits secretagogue-induced cAMP production and amylase secretion by Gi proteins in pancreatic acini.},
  author={Danuta Stryjek-Kaminska and Albrecht Piiper and Stefan Zeuzem},
  journal={The American journal of physiology},
  year={1995},
  volume={269 5 Pt 1},
  pages={G676-82}
}
In pancreatic acinar cells, the epidermal growth factor (EGF) receptor interacts with both cholera toxin- and pertussis toxin (PTX)-sensitive G proteins. In the present study, isolated rat pancreatic acini were used to investigate the effect of EGF on basal and secretagogue-induced adenosine 3',5'-cyclic monophosphate (cAMP) production and amylase release. EGF increased cAMP production and amylase release in pancreatic acini. However, cAMP accumulation and amylase release elicited by either… CONTINUE READING

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