EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer

@article{Kedmi2015EGFIM,
  title={EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer},
  author={Merav Kedmi and Nir Ben-Chetrit and Cindy K{\"o}rner and Maicol Mancini and Noa Bossel Ben-Moshe and Mattia Lauriola and Sara Lavi and Francesca Biagioni and Silvia L. Carvalho and Hadas Cohen-Dvashi and F Schmitt and Stefan Wiemann and Giovanni Blandino and Yosef Yarden},
  journal={Science Signaling},
  year={2015},
  volume={8},
  pages={ra29-ra29}
}
Growth factors promote tumor growth and metastasis. We found that epidermal growth factor (EGF) induced a set of 22 microRNAs (miRNAs) before promoting the migration of mammary cells. These miRNAs were more abundant in human breast tumors relative to the surrounding tissue, and their abundance varied among breast cancer subtypes. One of these miRNAs, miR-15b, targeted the 3′ untranslated region of MTSS1 (metastasis suppressor protein 1). Although xenografts in which MTSS1 was knocked down grew… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 14 times over the past 90 days. VIEW TWEETS
20 Citations
66 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 66 references

cancer cells

  • S. X. Atwood M. Bershteyn, W. M. Woo, M. Li
  • 2014

SCF b - TRCP targets MTSS 1 for ubiquitination - mediated destruction to regulate cancer cell proliferation and migration

  • S. Shaik Zhong, L. Wan, +4 authors W. Wei
  • Oncotarget
  • 2013

A HER2-Notch3 collaboration enables luminal filling

  • C.R.Pradeep, W.J.Köstler, +13 authors Modeling ductal carcinoma in situ
  • Oncogene 31, 907–917
  • 2012

Similar Papers

Loading similar papers…