EGF induces CREB and ERK activation at the wall of the mouse lateral ventricles.

@article{Gampe2011EGFIC,
  title={EGF induces CREB and ERK activation at the wall of the mouse lateral ventricles.},
  author={Kristine Gampe and Monika S. Brill and Stefan Momma and Magdalena G{\"o}tz and Herbert Zimmermann},
  journal={Brain research},
  year={2011},
  volume={1376},
  pages={31-41}
}
The subependymal zone at the lateral ventricular wall represents a major neurogenic niche of the adult mammalian brain and continuously provides new neurons for the olfactory bulb. A mosaic of stem and progenitor cells in this niche has the potential to respond to multiple signals including growth factors such as EGF. Recent studies using long-term ventricular infusion of EGF demonstrate intense cell proliferation around the ventricular wall, implicating the presence of EGF-reactive cells also… CONTINUE READING