EGF-induced activation of the EGF receptor does not trigger mobilization of caveolae.

@article{Kazazic2006EGFinducedAO,
  title={EGF-induced activation of the EGF receptor does not trigger mobilization of caveolae.},
  author={Maja Kazazic and Kirstine Roepstorff and Lene E. Johannessen and Nina Marie Pedersen and Bo van Deurs and Elden J. Stang and Inger Helene Madshus},
  journal={Traffic},
  year={2006},
  volume={7 11},
  pages={
          1518-27
        }
}
Caveolae-dependent endocytosis has recently been proposed in the uptake of EGF receptor (EGFR) at high concentrations of ligand. Consistently, upon incubation of HEp2 and HeLa cells with methyl-beta-cyclodextrin, we observed a small inhibitory effect on endocytosis of ligated EGFR in HEp2 cells. However, immunoelectron microscopy showed the same relative amount of bound EGF localizing to caveolae on incubation with high and low concentrations of EGF, not supporting rapid recruitment of EGFR to… CONTINUE READING
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EGF - induced activation of the EGF receptor does not trigger mobilization of caveolae

M. Kazazic, K. Roepstorff, +3 authors E. Stang
  • 2006