EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.

@article{Ji2009EGFinducedEA,
  title={EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.},
  author={Haitao Ji and Ji Zheng Wang and Heinz Nika and David J. Hawke and Susan M Keezer and Qingyuan Ge and Bingliang Fang and Xuexun Fang and Dexing Fang and David W. Litchfield and Kenneth D. Aldape and Zhimin Lu},
  journal={Molecular cell},
  year={2009},
  volume={36 4},
  pages={547-59}
}
Increased transcriptional activity of beta-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been detected in many types of human cancer, but the underlying mechanism of Wnt-independent regulation remains unclear. We demonstrate here that EGFR activation results in disruption of the complex of beta-catenin and alpha-catenin, thereby abrogating the inhibitory effect of alpha-catenin on beta-catenin transactivation via CK2alpha-dependent phosphorylation of alpha-catenin… CONTINUE READING
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