EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors.

@article{Avraham2010EGFDT,
  title={EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors.},
  author={Roi Avraham and Aldema Sas-Chen and Ohad Manor and Israel Steinfeld and Reut Shalgi and Gabi Tarcic and Noa Bossel and Amit Zeisel and Ido Amit and Yaara Zwang and Espen Enerly and Hege Giercksky Russnes and Francesca Biagioni and Marcella Mottolese and Sabrina Strano and Giovanni Blandino and Anne-Lise B{\o}rresen-Dale and Yitzhak Pilpel and Zohar Yakhini and Eran Segal and Yosef Yarden},
  journal={Science signaling},
  year={2010},
  volume={3 124},
  pages={
          ra43
        }
}
Epidermal growth factor (EGF) stimulates cells by launching gene expression programs that are frequently deregulated in cancer. MicroRNAs, which attenuate gene expression by binding complementary regions in messenger RNAs, are broadly implicated in cancer. Using genome-wide approaches, we showed that EGF stimulation initiates a coordinated transcriptional program of microRNAs and transcription factors. The earliest event involved a decrease in the abundance of a subset of 23 microRNAs. This… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 72 CITATIONS, ESTIMATED 60% COVERAGE

Transcriptional Dynamics Reveal Critical Roles for Non-coding RNAs in the Immediate-Early Response

  • PLoS computational biology
  • 2015
VIEW 24 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Transcriptional Dynamics Reveal Critical Roles for Non-coding RNAs in the Immediate-Early Response

  • PLoS Computational Biology
  • 2015
VIEW 24 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Molecularly Distinct Clath rin-Coated Pits Differentially Impact EGFR Fate and Signaling Graphical Abstract Highlights

Roberta Pascolutti, Veronica Algisi, +18 authors Sara Sigismund
  • 2019
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2011
2019

CITATION STATISTICS

  • 8 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors

Z. Yakhini
  • Sci . Signal .
  • 2010

A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling

C. D. Goodman R. Saba, R. L. Huzarewich, C. Robertson, S. A. Booth
  • Cell
  • 2009

Control of inducible gene expression by signaldependent transcriptional elongation

D. Braas V. R. Ramirez-Carrozzi, D. M. Bhatt, +6 authors S. T. Smale
  • Cell
  • 2009

Estradiol - regulatedmicroRNAs control estradiol response in breast cancer cells

J. S. Carroll, E. F. Srour, Y. Liu, H. Nakshatri
  • Nucleic Acids Res .
  • 2009

Lauffenburger , Quantitative modeling perspectives on the ErbB system of cell regulatory processes

M. J. Lazzara, A. D.
  • Exp . Cell Res .
  • 2009